On insulin secretion

Insulin Secretion

Insulin is secreted from the -cells of the pancreatic islets by Ca 2 -dependent exocytosis of large dense core vesicles (LDCVs) (Ämmälä et al., 1993), a process that is triggered by glucose-induced electrical activity (Henquin and Meissner, 1984). In response to a step elevation of glucose, insulin secretion follows a characteristic biphasic time course (Curry et al., 1968): an initial transien...

study of comparative effects of harmine and ghrelin agonist on insulin and c-peptide secretion

Aim and Background: The ability to secrete insulin from the islets of Langerhans on the one hand and suppress the factors that increase serum glucose concentrations on the other; It is very important in patients with metabolic disorders such as diabetes. The aim of this study was to compare the effects of harmine with ghrelin agonist (as a suppressor of insulin secretion) on insulin secretion a...

Effect of growth hormone on insulin secretion.

MALAISE, WILLY J., FRANCXNE MALAISSE-LAGAE, SUZANNE KING, ANII PETER H. WRIGHT. Efect of growth hormone on insulin secretion. Am. J. Physiol. 215(2) : 4-23-428. 1968.pInsulin secretion by pancreatic tissue or isolated islets of the normal rat is not affected by addition of ovine or rat growth hormone to the incubation medium. Pancreatic tissue removed from hypophysectomized rats secretes an abn...

Insulin Secretion and Actions

Islet Biology/Insulin Secretion

duces proinflammatory lipids that exacerbate β cell dysfunction and death. Inhibition of 12/15-LOX thereby provides a potential therapeutic approach to prevent glycemic deterioration in T1D, but to date no specific inhibitors have been tested T1D. Here we assessed the efficacy and mechanism of a novel and specific 12/15-LOX inhibitor, ML351. Using cultured β cells in vitro, ML351 exhibited no a...